Borsboom and colleagues have recently proposed a “network theory” of psychiatric disorders that conceptualizes psychiatric disorders as relatively stable networks of causally interacting symptoms. They have also claimed that the network theory should include non-symptom variables such as environmental factors. How are environmental factors incorporated in the network theory, and what kind of explanations of psychiatric disorders can such an “extended” network theory provide? The aim of this article is to critically examine what explanatory strategies the network theory that includes (...) both symptoms and environmental factors can accommodate. We first analyze how proponents of the network theory conceptualize the relations between symptoms and between symptoms and environmental factors. Their claims suggest that the network theory could provide insight into the causal mechanisms underlying psychiatric disorders. We assess these claims in light of network analysis, Woodward’s interventionist theory, and mechanistic explanation, and show that they can only be satisfied with additional assumptions and requirements. Then, we examine their claim that network characteristics may explain the dynamics of psychiatric disorders by means of a topological explanatory strategy. We argue that the network theory could accommodate topological explanations of symptom networks, but we also point out that this poses some difficulties. Finally, we suggest that a multilayer network account of psychiatric disorders might allow for the integration of symptoms and non-symptom factors related to psychiatric disorders and could accommodate both causal/mechanistic and topological explanations. (shrink)

Este artigo é um diálogo com Hegel e Gadamer, partindo da pergunta: "O que é arte?''. Hegel é um divisor de águas; pode-se dizer que a arte antes de Hegel é uma coisa e depois de Hegel outra. Com Hegel diremos que a arte "morreu" ou foi supra assumida pelo espírito absoluto; se isso não significa morte, é, pelo menos, perda de identidade - de autonomia. Com Gadamer diremos que a arte é arte, sem estar dizendo uma tautologia; pois essa (...) seria a melhor forma de dizer que arte não tem conceito e nem depende de conceito para ser arte; a arte é enquanto tal, sem pendências e sem dependências. (shrink)

In this paper we provide a defence of cosmopolitanism from a liberal perspective, examining its moral underpinnings, including moral obligations predicated on a belief in common humanity and the fundamental dignity of human people, cultural capacities that include an embrace of pluralism and a fallibilist disposition, and pragmatist resolve in finding humanitarian solutions to real problems that people face. We also scrutinise the ideal of cosmopolitanism by considering the ‘deeply religious’ as the sort of people about whom it may be (...) said that irreconcilable tensions exist between certain types of commitment and/or belonging and what the demands of cosmopolitanism involve. (shrink)

A scholarly edition of The Clarendon Edition of the Works of John Locke: Correspondence: Letters 2665-3286 by E. S. de Beer. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

A scholarly edition of The Clarendon Edition of the Works of John Locke: Correspondence: Letters 3287-3648 by E. S. de Beer. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

Este artigo é uma tentativa de mostrar, a partir de Gadamer, que o Mito está em estreita relação dialética com o Logos e que a compreensão de ambos pertence a um mesmo movimento circular e hermenêutico, que conecta os conceitos de indeterminado e determinada, incerto e certo, infinitude e finitude.

Psychiatric disorders present distinct clinical challenges which are partly attributable to their multifactorial aetiology and the absence of laboratory tests that can be used to confirm diagnosis or predict risk. Psychiatric disorders are highly heritable, but also polygenic, with genetic risk conferred by interactions between thousands of variants of small effect that can be summarized in a polygenic risk score. We discuss four areas in which the use of polygenic risk scores in psychiatric research and clinical contexts could have ethical (...) implications. First, there is concern that clinical use of polygenic risk scores may exacerbate existing health inequities. Second, research findings regarding polygenic risk could be misinterpreted in stigmatising or discriminatory ways. Third, there are concerns associated with testing minors as well as eugenics concerns elicited by prenatal polygenic risk testing. Fourth, potential challenges that could arise with the feedback and interpretation of high polygenic risk for a psychiatric disorder would require consideration. While there would be extensive overlap with the challenges of feeding back genetic findings in general, the potential clinical use of polygenic risk scoring warrants discussion in its own right, given the recency of this possibility. To this end, we discuss how lay interpretations of risk and genetic information could intersect. Consideration of these factors would be necessary for ensuring effective and constructive communication and interpretation of polygenic risk information which, in turn, could have implications for the uptake of any therapeutic recommendations. Recent advances in polygenic risk scoring have major implications for its clinical potential, however, care should be taken to ensure that communication of polygenic risk does not feed into problematic assumptions regarding mental disorders or support reductive interpretations. (shrink)

Anamnese - a filosofia e o retomo do reprimido, do professor Ernildo Stein, éum conjunto de doze ensaios, publicados em 1997 pela Editora da PUCRS, que nosbrinda com temas da relação Filosofia-Psicanálise, numa linguagem polêmica,associada a um estilo literário e livre. Sendo um livro de ensaios, não há exigênciade uma leitura seqüenciada, nem de conhecimento profundo de filosofia e psicanálise,mas, com certeza, o leitor será naturalmente lançado num campo muitofértil, cujas trilhas de discussão e as notáveis elaborações construídas são umconvite (...) ao estudo dos temas e problemas tratados. (shrink)

This article reports an empirical investigation of the cognitive effort required to decide in multiattribute binary choice using a variation of the Additive Difference strategy. In contrast with other studies, this paper focuses on the effect of various context variables (rather than task variables) on cognitive effort. In order to select the context variables to be manipulated, we used the model proposed by Shugan (1980; J. Consumer Res. 75 (1980) 99). Our results indicate that there is a positive relationship between (...) the cognitive effort required to decide and the mean of the differences between the dimensions of the choice alternatives. We have also found an inverse relationship between cognitive effort and the variance of the differences between the dimensions of the choice alternatives. Finally, we have found that in negative correlation contexts the effort needed to decide is greater than in positive and null correlation contexts. (shrink)

Demonstrates the validity of the measure presented in "Estimating Semantic Content" on textbook examples using (binary) resolution [a generalization of disjunctive syllogism] theorem proving; the measure is based on logical probability and is the mirror image of logical form; it dates to Popper.

We present a new approach to the mathematical objects of General Relativity in terms of which a generic f(R)-gravity theory gravitation is written in a first-order (à la Palatini) formalism, and introduce the concept of Dark Metric which could bypass the emergence of disturbing concepts as Dark Energy and Dark Matter. These issues are related to the fact that General Relativity could not be the definitive theory of Gravitation due to several shortcomings that come out both from theoretical and experimental (...) viewpoints. At large scales, the attempts to match it with the recent observational data lead to invoke Dark Energy and Dark Matter as the bulk components of the cosmic fluid. Since no final evidence, at fundamental level, exists for such ingredients, it could be useful to reconsider the gravitational sector in order to see if suitable extensions of General Relativity could solve the shortcomings present at infrared scales. (shrink)

A scholarly edition of The Clarendon Edition of the Works of John Locke: Correspondence: Letters 1242-1701 by E. S. de Beer. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

A scholarly edition of The Clarendon Edition of the Works of John Locke: Correspondence: Letters 1702-2198 by E. S. de Beer. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

Research indicates that consumers are particularly concerned about the safety of meat. More highly processed meat is perceived as more unsafe than fresh or natural meats, i.e., consumers trust processed meat less. This paper studies the relationship between perceived trust and day-to-day purchase behavior for meat, giving special attention to the degree of meat processing. Controlling for trust in food chain actors and demographic and socio-economic variables, actual meat purchases of Canadian households are linked to answers from a commissioned food (...) attitudes survey completed by the same households. Expenditures for processed and total meat (but not for fresh meat) are significantly different by three levels of trust in the food industry. Consumer with the lowest trust levels consume less (especially of processed meat) compared to those with higher trust levels. However, in a multivariate setting, trust shows no effect on fresh or processed meat purchases with or without demographic and socio-economic control variables, suggesting that the impact of trust on meat purchases is only small. However, the low trusting consumer segment could potentially be a target for marketing strategies focused on reputation and quality to increase sales in this particular group. (shrink)

The balance between births and deaths in an age-structured population is strongly influenced by the spatial distribution of sub-populations. Our aim was to describe the demographic process of a fish population in an hierarchical dendritic river network, by taking into account the possible movements of individuals. We tried also to quantify the effect of river network changes (damming or channelling) on the global fish population dynamics. The Salmo trutta life pattern was taken as an example for.We proposed a model which (...) includes the demographic and the migration processes, considering migration fast compared to demography. The population was divided into three age-classes and subdivided into fifteen spatial patches, thus having 45 state variables. Both processes were described by means of constant transfer coefficients, so we were dealing with a linear system of difference equations. The discrete case of the variable aggregation method allowed the study of the system through the dominant elements of a much simpler linear system with only three global variables: the total number of individuals in each age-class. (shrink)